2'-O-MOE Nucleosides
2'-O-MOE-rG
Quick view. We supply 2'-O-MOE-rG as a methoxyethyl guanosine nucleoside for MOE-modified oligonucleotide building blocks. CAS 473278-54-5. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-rG is classified as nucleoside or protected nucleoside intermediate (Formula C13H19N5O6; molecular weight 341.32).
2'-O-MOE-rG — A guanosine derivative as building blocks for cross-linking oligonucleotides.
For 2'-O-MOE-rG, reported solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml DMSO: Sparingly Soluble: 1-10 mg/ml Water: Slightly Soluble: 0.1-1 mg/ml. Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-MOE-rG
- 2'-O-MOE-Gr
- 2'-O-Methoxyethyl-guanosine
- 2'-O-(2-Methoxyethyl)guanosine
- Guanosine, 2'-O-(2-Methoxyethyl)-
Useful catalog search terms
- CAS 473278-54-5
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Boiling point | 715.0±70.0 °C(Predicted) |
| Density | 1.81±0.1 g/cm3(Predicted) |
| pKa | 13.20±0.70(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OCCOC)[C@@H]1O |
| InChI | InChI=1S/C13H19N5O6/c1-22-2-3-23-9-8(20)6(4-19)24-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h5-6,8-9,12,19-20H,2-4H2,1H3,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s |
| InChIKey | DLLBJSLIKOKFHE-WOUKDFQISA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-MOE-rG can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rG or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-rG be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0168 and CAS 473278-54-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.