Protected Nucleosides
2'-O-TBDMS-guanosine
Quick view. We supply 2'-O-TBDMS-guanosine as a silyl-protected ribonucleoside intermediate for RNA monomer and specialty nucleoside synthesis. CAS 72409-41-7. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-O-TBDMS-guanosine is classified as nucleoside or protected nucleoside intermediate (Formula C16H27N5O5Si; molecular weight 397.5).
2'-O-TBDMS-guanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-TBDMS-guanosine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 2'-O-(tert-butyl-dimethyl-silanyl)-guanosine
- Guanosine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl]- (9CI)
Useful catalog search terms
- CAS 72409-41-7
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection |
|---|---|
| Density | 1.46±0.1 g/cm3(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
2'-O-TBDMS-rG(iBu)
Protected Nucleosides · CAS: 182007-86-9
BX-PN-00435'-O-DMTr-2'-O-TBDMS-rC(Ac)
Protected Nucleosides · CAS: 121058-85-3
BX-PN-00575'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC
Protected Nucleosides · CAS: 1257247-39-4
BX-PN-00585'-O-TBDMS-3'-O-TBDMS-5-I-dC
Protected Nucleosides · CAS: 478843-96-8
BX-PN-00607'-O-TBDMS-4'-N-Trt-PMO-G(iBu)
Protected Nucleosides · CAS: N/A
BX-PN-00673'-O-TBDMS-2'-F-dG(iBu)
Protected Nucleosides · CAS: 2382967-92-0
Frequently asked questions
Can the package size for 2'-O-TBDMS-guanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0274 and CAS 72409-41-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.