Modified Nucleotides
2'-OMe-GTP Sodium Salt
Quick view. We supply 2'-OMe-GTP Sodium Salt as a 2'-O-methyl nucleotide used to prepare or evaluate modified RNA with improved nuclease resistance and altered immune recognition. CAS 61556-44-3. Catalog target purity: Specification on request.
Product profile
2'-OMe-GTP Sodium Salt is classified as nucleotide or nucleotide analog (Formula C11H18N5O14P3; molecular weight 537.21).
2'-OMe-GTP Sodium Salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For 2'-OMe-GTP Sodium Salt, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- Gm(5')ppp
- 2'-O-methylguanosine 5'-triphosphate
- Guanosine 5'-(tetrahydrogen triphosphate), 2'-o-methyl-
- 9-[5-O-(Hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-2-O-methylpentofuranosyl]-2-imino-3,9-dihydro-2H-purin-6-ol
Useful catalog search terms
- CAS 61556-44-3
- Nucleotide or nucleotide analog
- 2'-O-methyl modification
- triphosphate group
- Modified Nucleotides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification; triphosphate group |
|---|---|
| InChI | InChI=1S/C11H18N5O14P3/c1-26-7-6(17)4(2-27-32(22,23)30-33(24,25)29-31(19,20)21)28-10(7)16-3-13-5-8(16)14-11(12)15-9(5)18/h3-4,6-7,10,17H,2H2,1H3,(H,22,23)(H,24,25)(H2,19,20,21)(H3,12,14,15,18)/t4-,6-,7-,10-/m1/s |
| InChIKey | GMUJBFZJAFFHIW-KQYNXXCUSA-N |
| SMILES | CO[C@@H]1[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O[C@H]1n1cnc2c(O)nc(=N)[nH]c21 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-OMe-GTP Sodium Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-OMe-GTP Sodium Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MODN-0162 and CAS 61556-44-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleotides product family and its named chemistry.