Modified Nucleotides
2'-OMe-GTP Sodium Salt
Quick view. 2'-OMe-GTP Sodium Salt is the sodium-salt form of 2'-O-methylguanosine 5'-triphosphate. The published structure and identity values describe the counterion-free parent; sodium stoichiometry is not specified. Parent/free-acid CAS 61556-44-3; this identifier does not represent the complete catalog product form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Structure
Structure form boundary. The displayed drawing omits catalog counterions and does not establish the complete supplied form, counterion stoichiometry or hydration state.
Identity of the displayed counterion-free structure
Scope. These values describe only the counterion-free structure shown above. They do not identify the complete catalog salt or establish counterion stoichiometry.
| Depicted identity | 2'-O-Methylguanosine 5'-triphosphate |
|---|---|
| Depicted form | Counterion-free structure |
| Source database | PubChem |
| PubChem CID | 135446965 |
| Molecular formula | C11H18N5O14P3 |
| Molecular weight | 537.21 g/mol |
| InChIKey | GMUJBFZJAFFHIW-KQYNXXCUSA-N |
Machine-readable identifiers for the displayed structure
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O |
|---|---|
| Connectivity SMILES | COC1C(C(OC1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O |
| InChI | InChI=1S/C11H18N5O14P3/c1-26-7-6(17)4(2-27-32(22,23)30-33(24,25)29-31(19,20)21)28-10(7)16-3-13-5-8(16)14-11(12)15-9(5)18/h3-4,6-7,10,17H,2H2,1H3,(H,22,23)(H,24,25)(H2,19,20,21)(H3,12,14,15,18)/t4-,6-,7-,10-/m1/s1 |
Form boundary. The reviewed public records establish the displayed counterion-free parent identity. They do not establish sodium stoichiometry or the complete catalog salt form.
Identifier context
These notes preserve the current catalog identifiers while making their review boundary explicit.
Parent/free-acid CAS 61556-44-3 identifies the counterion-free parent only; it is not an unconditional identifier for the complete sodium-salt product. Confirm sodium stoichiometry and supplied form in the quote request.
Product profile
2'-OMe-GTP Sodium Salt is classified as modified nucleotides.
2'-OMe-GTP Sodium Salt supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-OMe-GTP Sodium Salt, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-methylguanosine 5'-triphosphate
- Gm(5')ppp
Useful catalog search terms
- 2'-O-Me-GTP Sodium Salt
- Modified Nucleotides
Physicochemical data
| Parent/free-acid CAS | 61556-44-3 |
|---|---|
| CAS basis | Parent/free-acid identity only; not the complete catalog sodium-salt form |
| CAS publication scope | parent-free-acid-only |
| Free-acid molecular formula | C11H18N5O14P3 |
| Free-acid molecular weight | 537.21 |
| Sodium-salt identity status | Complete sodium-salt stoichiometry, formula and molecular weight pending exact-form source verification |
| Salt form | Sodium salt; stoichiometry not specified |
| Chemical feature | 2'-O-methyl ribonucleoside triphosphate |
| Structure representation | Stereospecific 2'-O-methyl-GTP free-acid parent; sodium stoichiometry is not represented |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-OMe-GTP Sodium Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-OMe-GTP Sodium Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MODN-0162 and Parent/free-acid CAS 61556-44-3 (not a complete catalog-product CAS), the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.