Protected Nucleosides
3'-O-TBDMS-2'-dG(iBu)
Quick view. We supply 3'-O-TBDMS-2'-dG(iBu) as a silyl-protected ribonucleoside intermediate for RNA monomer and specialty nucleoside synthesis. CAS 99540-94-0. Catalog target purity: Specification on request.
Product profile
3'-O-TBDMS-2'-dG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C20H33N5O5Si; molecular weight 451.59).
3'-O-TBDMS-2'-dG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-TBDMS-2'-dG(iBu), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-N2-iBu-dG
- 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-
- Guanosine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-
Useful catalog search terms
- CAS 99540-94-0
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-2'-dG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0115 and CAS 99540-94-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.