Amino-modified Nucleosides
5-(Azidomethyl)-2'-deoxyuridine
Quick view. We supply 5-(Azidomethyl)-2'-deoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 59090-48-1. Catalog target purity: Specification on request.
Product profile
5-(Azidomethyl)-2'-deoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C10H13N5O5; molecular weight 283.24 g/mol (calculated from molecular formula)).
5-(Azidomethyl)-2'-deoxyuridine — 5-Azidomethyl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog. 5-Azidomethyl-2'-deoxyuridine demonstrates effective radiosensitization in EMT6 tumor cells.. 5-Azidomethyl-2'-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with…
For 5-(Azidomethyl)-2'-deoxyuridine, reported solubility: Soluble in Water, alcohols, DMSO, DMF. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 5-(Azidomethyl)-1-(2-deoxypentofuranosyl)-4-hydroxypyrimidin-2(1H)-one
- α-Azidothymidine
Useful catalog search terms
- CAS 59090-48-1
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C10H13N5O5/c11-14-12-2-5-3-15(10(19)13-9(5)18)8-1-6(17)7(4-16)20-8/h,6-8,16-17H,1-2,4H2,(H,13,18,19) |
| InChIKey | JKSAKMHLWMCADM-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCc1cn(C2CC(O)C(CO)O2)c(=O)nc1O |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-(Azidomethyl)-2'-deoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5-(Azidomethyl)-2'-deoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-(Azidomethyl)-2'-deoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0223 and CAS 59090-48-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-(Azidomethyl)-2'-deoxyuridine or the named structural feature represented by this product.