Amino-modified Nucleosides
5-(N-Methyl-N-trifluoroacetyl-aminomethyl)-2-thiouridine
Quick view. A C5 amino-functionalized 2-thiouridine carrying an N-methyl-N-trifluoroacetyl-protected aminomethyl substituent, identified by CAS 89128-99-4. CAS 89128-99-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-(N-Methyl-N-trifluoroacetyl-aminomethyl)-2-thiouridine is classified as amino-modified nucleosides (Formula C13H16F3N3O6S; molecular weight 399.34).
5-(N-Methyl-N-trifluoroacetyl-aminomethyl)-2-thiouridine — Protected amino-functionalized 2-thiouridine intermediate for further nucleoside chemistry
For 5-(N-Methyl-N-trifluoroacetyl-aminomethyl)-2-thiouridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Useful catalog search terms
- CAS 89128-99-4
Physicochemical data
| Nucleoside scaffold | 2-Thiouridine |
|---|---|
| C5 substituent | N-methyl-N-trifluoroacetylaminomethyl |
| Amine state | Trifluoroacetyl-protected N-methyl amine |
| Free hydroxyl groups | 2', 3', and 5' |
| PubChem CID | 10834741 |
| InChI | InChI=1S/C13H16F3N3O6S/c1-18(11(24)13(14,15)16)2-5-3-19(12(26)17-9(5)23)10-8(22)7(21)6(4-20)25-10/h3,6-8,10,20-22H,2,4H2,1H3,(H,17,23,26)/t6-,7-,8-,10-/m1/s1 |
| InChIKey | JSJWOXIZNRMGDB-FDDDBJFASA-N |
| SMILES | CN(CC1=CN(C(=S)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)C(F)(F)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-(N-Methyl-N-trifluoroacetyl-aminomethyl)-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-(N-Methyl-N-trifluoroacetyl-aminomethyl)-2-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0240 and CAS 89128-99-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.