Protected Nucleosides
5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine
Quick view. We supply 5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine as a protected nucleoside intermediate for DNA/RNA analog synthesis and medicinal chemistry workflows. CAS 127212-40-2. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine is classified as nucleoside or protected nucleoside intermediate (Formula C31H32N2O8; molecular weight 560.59).
5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-methyl-
Useful catalog search terms
- CAS 127212-40-2
- Nucleoside or protected nucleoside intermediate
- Protected Nucleosides
Physicochemical data
| Density | 1.35±0.1 g/cm3(Predicted) |
|---|---|
| pKa | 9.39±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0360 and CAS 127212-40-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.