Protected Nucleosides
5'-O-(4,4'-Dimethoxytrityl)adenosine
Quick view. We supply 5'-O-(4,4'-Dimethoxytrityl)adenosine as a protected nucleoside intermediate for DNA/RNA analog synthesis and medicinal chemistry workflows. CAS 81352-25-2. Catalog target purity: Specification on request.
Product profile
5'-O-(4,4'-Dimethoxytrityl)adenosine is classified as nucleoside or protected nucleoside intermediate (Formula C31H31N5O6; molecular weight 569.61).
5'-O-(4,4'-Dimethoxytrityl)adenosine — 5''-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine is an oligonucleotide used in the synthesis of oligonucleotides carrying fluorescently labeled O6-alkylguanine for measuring hAGT activity.
For 5'-O-(4,4'-Dimethoxytrityl)adenosine, storage: 2-8°C(protect from light). Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine
- 5'-DMT-rA
- 5'-O-DMT-adenosine
- 5'-O-dimethoxytrityladenosine
- Adenosine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-
Useful catalog search terms
- CAS 81352-25-2
- Nucleoside or protected nucleoside intermediate
- Protected Nucleosides
Physicochemical data
| InChI | InChI=1S/C31H31N5O6/c1-39-22-12-8-20(9-13-22)31(19-6-4-3-5-7-19,21-10-14-23(40-2)15-11-21)41-16-24-26(37)27(38)30(42-24)36-18-35-25-28(32)33-17-34-29(25)36/h3-15,17-18,24,26-27,30,37-38H,16H2,1-2H3,(H2,32,33,34)/t24-,26-,27-,30-/m1/s |
|---|---|
| InChIKey | KOQFCLKBHJBRTB-WMPYGVGNNA-N |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)N)N=C2)[C@H](O)[C@@H]1O |&1:25,27,38,40,r| |
| Melting point | 145-147 °C |
| Boiling point | 812.0±75.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| pKa | 13.08±0.70(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-(4,4'-Dimethoxytrityl)adenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-(4,4'-Dimethoxytrityl)adenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0293 and CAS 81352-25-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.