2'-O-Me Phosphoramidites
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite
Quick view. We supply 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite as a POM-masked 5'-vinyl phosphonate uridine amidite for terminally modified oligonucleotide synthesis. CAS 2172373-55-4. Catalog target purity: Specification on request.
Product profile
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C32H52N4O13P2; molecular weight 762.73).
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite, storage: 2-8°C, protect from light, stored under nitrogen.
Names and search terms
Confirmed or normalized name variants
- 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-2-cyanoethyl phosphoramidite
- 5'(E)-VP-2'-OMe-U Phosphoramidite
- BX-5EVP-0002
Useful catalog search terms
- CAS 2172373-55-4
- Protected oligonucleotide phosphoramidite building block
- 2'-O-methyl modification
- phosphoramidite coupling group
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification; phosphoramidite coupling group |
|---|---|
| SMILES | O([C@@H]1[C@H](O[C@@H](N2C=CC(=O)NC2=O)[C@@H]1OC)/C=C/P(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)P(OCCC#N)N(C(C)C)C(C)C |&1:1,2,4,13,r| |
| InChIKey | AJJPYIXDIHURAB-HXBNXGDYNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0071 and CAS 2172373-55-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.