Cyclic Dinucleotides
c-di-GMP sodium salt
Quick view. We supply c-di-GMP sodium salt as a dry material for bacterial signaling and cyclic-dinucleotide assay development. CAS 2222132-40-1. Catalog target purity: ≥98%.
Product profile
c-di-GMP sodium salt is classified as cyclic dinucleotide second messenger or analog (Formula C20H22N10Na2O14P2; molecular weight 734.37).
c-di-GMP sodium salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For c-di-GMP sodium salt, reported solubility: Soluble in water; confirm lot-specific concentration limits. Storage: −20 °C.
Names and search terms
Confirmed or normalized name variants
- Cyclic di-GMP sodium
- c-di-guanosine monophosphate sodium salt
- Cyclic-di-GMP disodium
- Cyclic di-GMP (sodium salt)
Useful catalog search terms
- CAS 2222132-40-1
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Purity basis | Research-grade target; the lot-specific CoA reports the release result and analytical method. |
| Counterion | Sodium |
| Supply form | Dry salt |
| Form | A crystalline solid |
| Color | Off-white to light yellow |
| SMILES | O=P(O[C@H]1[C@H]([C@H](N6C=NC7=C6N=C(NC7=O)N)O[C@@H]1CO2)O)(O[Na])OC[C@@H]3[C@H]([C@H]([C@H](N4C=NC5=C4N=C(NC5=O)N)O3)O)OP2(O[Na])=O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe c-di-GMP sodium salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for c-di-GMP sodium salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0017 and CAS 2222132-40-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response