Other Phosphoramidites
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite as a difluoro nucleoside phosphoramidite for incorporating geminal fluorine-modified residues into oligonucleotides. CAS 142808-44-4. Catalog target purity: Specification on request.
Product profile
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C46H50F2N5O8P; molecular weight 869.89).
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- DMTr-2’,2’-di fluoro-dC(Bz)-3’-CED-phosphoramidite
- N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite
- N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine
- 5'-O-DMT-N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine 3'-CE phosphoramidite
- N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
- DMT-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite
- DMTr-2',2'-diFluoro-dC(Bz)-3'-2-cyanoethyl phosphoramidite
Useful catalog search terms
- CAS 142808-44-4
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- phosphoramidite coupling group
- Other Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-OP-0014 and CAS 142808-44-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry.