2'-Fluoro Phosphoramidites
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite as a core 2'-F adenosine amidite for modified RNA-like oligonucleotides. CAS 136834-22-5. Catalog target purity: Specification on request.
Product profile
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H51FN7O7P; molecular weight 875.92).
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite — (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is an adenosine derivative used in the preparation of modified nucleotides to improve metabolic stability and ellicit gene silencing, and in the synthesis of microRNA…
For DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite, storage: Inert atmosphere,Store in freezer, under -20°C. Form: Powder.
Names and search terms
Confirmed or normalized name variants
- Bz-2'-F-dA Phosphoramidite
- Dmt-2'fluoro-da(bz) amidite
- 2'-F-N6-Bz-dA phosphoramidite
- 2'-F-dA(Bz)-CE Phosphoramidite
- 5'-DMT-2'-F-Bz-dA Phosphoramidite
- DMT-2'-F-dA(Bz)-CE Phosphoramidite
- N6-Bz-5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-CE-Phosphoramidite
- DMT-2'-F-dA(Bz)-3'-CE-Phosphoramidite
Useful catalog search terms
- CAS 136834-22-5
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-fluoro modification
- phosphoramidite coupling group
- 2'-F-dA(Bz) Phosphoramidite
- BX-2FP-0015
- 2'-Fluoro Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification; phosphoramidite coupling group |
|---|---|
| Form | Powder |
| Color | White to off-white |
| InChIKey | ZDIBABNMVQPXHU-JWQXGDSTNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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BX-2FP-0006DMTr-2'-F-dG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0026 and CAS 136834-22-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry.