2'-Fluoro Phosphoramidites
DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite as a benzoyl-protected 2'-F cytidine CE amidite for solid-phase oligonucleotide synthesis. CAS 161442-19-9. Catalog target purity: Specification on request.
Product profile
DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C46H51FN5O8P; molecular weight 851.9).
DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite — 2'-Fluoro-N4-benzoyl-5'-O-DMT-2'-deoxycytidine-3'-ce-phosphoramidite is a fluorescent oligonucleotide RNA probe. 2'-Fluoro-N4-benzoyl-5'-O-DMT-2'-deoxycytidine-3'-ce-phosphoramidite is also used to improve metabolic stability and elicit efficient RNAi-mediated gene silencing.
For DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite, reported solubility: DMSO: 100 mg/mL (117.38 mM; Need ultrasonic). Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- Bz-2'-F-dC Phosphoramidite
- N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-cytidine phosphoramidite
- N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-cytidine 3-CE phosphoramidite
- 2''-Fluoro-n4-benzoyl-5''-o-dmt-2''-deoxycytidine-3''-ce-phosphoramidite
- N4-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-CE-Phosphoramidite
- DMT-2'-F-dC(Bz)-3'-CE-Phosphoramidite
- DMTr-2'-F-dC(Bz)-3'-2-cyanoethyl phosphoramidite
- 2'-F-dC(Bz) Phosphoramidite
Useful catalog search terms
- CAS 161442-19-9
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-fluoro modification
- phosphoramidite coupling group
- BX-2FP-0016
- 2'-Fluoro Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to light yellow |
| SMILES | C(NC1C=CN([C@H]2[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O2)C(=O)N=1)(=O)C1=CC=CC=C1 |&1:6,7,9,24,r| |
| InChIKey | DBKYISAGLSNHRB-VDQODKCANA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2FP-0003DMTr-2'-F-dC(Bz)-3'-(D)-DPSE-Phosphoramidite
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BX-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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BX-2FP-0006DMTr-2'-F-dG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0028 and CAS 161442-19-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry.