2'-Fluoro Phosphoramidites
DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite as a standard 2'-F guanosine CE amidite for RNA and therapeutic-oligo chemistry. CAS 144089-97-4. Catalog target purity: Specification on request.
Product profile
DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C44H53FN7O8P; molecular weight 857.91).
DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite — DMT-2''Fluoro-DG(IB) amidite (CAS# 144089-97-4) is a nucleoside used in the preparation of cyclic dinucleotide compounds, and in the preparation of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides, which improve metabolic stability and elicit efficient RNAi-mediated gene silencing.
For DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite, reported solubility: DMSO: 100 mg/mL (116.56 mM). Storage: -20°C.
Names and search terms
Confirmed or normalized name variants
- DMT-2FLUORO-DG(IB) AMIDITE
- ibu-2'-F-dG Phosphoramidite
- 2'-F-dG(iBu)-CE Phosphoramidite
- DMT-2'-F-dG(iBu)-CE Phosphoramidite
- 5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-Deoxy-guanosine 3'-CE phosphoramidite
- DMT-2'-F-dG(iBu)-3'-CE-Phosphoramidite
- DMTr-2'-F-dG(iBu)-3'-2-cyanoethyl phosphoramidite
- 2'-F-dG(ibu) Phosphoramidite
Useful catalog search terms
- CAS 144089-97-4
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-fluoro modification
- phosphoramidite coupling group
- BX-2FP-0017
- 2'-Fluoro Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification; phosphoramidite coupling group |
|---|---|
| Form | powder |
| Color | white to off-white |
| SMILES | C(NC1=NC(=O)C2=C(N1)N([C@H]1[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C(C)C |&1:10,11,13,28,r| |
| InChIKey | CFFUQMXILRDKMM-QPYLYBSMNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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BX-2FP-0006DMTr-2'-F-dG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0027 and CAS 144089-97-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry.