2'-Fluoro Phosphoramidites
DMTr-2'-F-dU-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-F-dU-3'-CE-Phosphoramidite as the routine CE version of 2'-F-dU for solid-phase oligonucleotide synthesis. CAS 146954-75-8. Catalog target purity: Specification on request.
Product profile
DMTr-2'-F-dU-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C39H46FN4O8P; molecular weight 748.78).
DMTr-2'-F-dU-3'-CE-Phosphoramidite — 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.
For DMTr-2'-F-dU-3'-CE-Phosphoramidite, reported solubility: DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml. Storage: Sealed in dry,Store in freezer, under -20°C.
Names and search terms
Confirmed or normalized name variants
- 2'-Fluoro-dU CEP
- 2’-F-rUPhosphoramidite
- 2'-F-dU Phosphoramidite
- 5'-O-DMT-2'-F-dU-3'-CEDPA
- 5'-DMT-2'-F-rU Phosphoramidite
- DMT-2′Fluoro-dU Phosphoramidite
- 2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine Phosphoramidite
- 5'-O-DMT-2'-Fluoro-2'-deoxyuridine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 146954-75-8
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-fluoro modification
- phosphoramidite coupling group
- BX-2FP-0018
- 2'-Fluoro Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification; phosphoramidite coupling group |
|---|---|
| Form | powder |
| Color | white to off-white |
| SMILES | N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F |&1:8,10,36,51,r| |
| InChIKey | HQHQPAYRJJMYQX-YOKGOYKLNA-N |
| InChI | InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-F-dU-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-F-dU-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0024 and CAS 146954-75-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry.