2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite as a standard 2'-O-methyl guanosine amidite for modified RNA, ASO and siRNA synthesis. CAS 150780-67-9. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C45H56N7O9P; molecular weight 869.94).
DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite — 2''-OMe-ibu-G Phosphoramidite (CAS# 150780-67-9) is used in the synthesis of native-like crosslinked duplex RNA via interstrand crosslinking reaction between vinylpurine on one strand and target cytosine or uracil on the opposite strand.
For DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite, reported solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated). Storage: Inert atmosphere,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-ibu-G Phosphoramidite
- ibu-2'-OMe-G Phosphoramidite
- 2'-OMe-G(ibu) Phosphoramidite
- 2'-OMe-G(iBu)-3'-phosphoramidit
- 2'-OMe-G(iBu)-3'-phosphoramidite
- 5'-O-DMT-2'-O-Me-rG(N-iBu)-3'-CEDPA
- 2’-O-methyl-rG(N-ibu)Phosphoramidite
- DMT-2'-OME-dG(Bz)-CE-Phosphoramidite
Useful catalog search terms
- CAS 150780-67-9
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-methyl modification
- phosphoramidite coupling group
- BX-2OMP-0050
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification; phosphoramidite coupling group |
|---|---|
| Melting point | 138 - 140°C |
| Form | powder |
| Color | white to off-white |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,44,47,r| |
| InChIKey | IRRDHRZUOZNWDJ-MLLDKZSOSA-N |
| InChI | InChI=1S/C45H56N7O9P/c1-28(2)41(53)49-44-48-40-37(42(54)50-44)47-27-51(40)43-39(57-9)38(61-62(59-25-13-24-46)52(29(3)4)30(5)6)36(60-43)26-58-45(31-14-11-10-12-15-31,32-16-20-34(55-7)21-17-32)33-18-22-35(56-8)23-19-33/h10-12,14-23,27-30,36,38-39,43H,13,25-26H2,1-9H3,(H2,48,49,50,53,54)/t36-,38-,39-,43-,62?/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0075 and CAS 150780-67-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.