cEt-BNA
DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite as a constrained ethyl BNA phosphoramidite for high-affinity therapeutic oligonucleotide synthesis. CAS 945628-66-0. Catalog target purity: Specification on request.
Product profile
DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C46H56N7O9P; molecular weight 881.95).
DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite — 5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity.
For DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite, form: Solid.
Names and search terms
Confirmed or normalized name variants
- CET-rG(ibu) Phosphoramidite
- N6-Bz-2'-O-4'-G-Locked-Gr-CET-Phosphoramidite
- (1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl)
- DMT-S-cEt-rG(iBu)-3'-CE-Phosphoramidite
- DMTr-S-cEt-rG(iBu)-3'-2-cyanoethyl phosphoramidite
Useful catalog search terms
- CAS 945628-66-0
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- conformationally locked sugar
- phosphoramidite coupling group
- cEt-BNA
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| InChI | InChI=1S/C46H56N7O9P/c1-28(2)41(54)50-44-49-40-37(42(55)51-44)48-27-52(40)43-38-39(62-63(59-25-13-24-47)53(29(3)4)30(5)6)45(61-43,31(7)60-38)26-58-46(32-14-11-10-12-15-32,33-16-20-35(56-8)21-17-33)34-18-22-36(57-9)23-19-34/h10-12,14-23,27-31,38-39,43H,13,25-26H2,1-9H3,(H2,49,50,51,54,55)/t31-,38+,39-,43+,45-,63?/m0/s |
| InChIKey | VMDSRWMHPUGGSZ-KHGLYSIJSA-N |
| SMILES | COc1ccc(C(OC[C@]23O[C@@H](n4cnc5c(O)nc(NC(=O)C(C)C)nc54)[C@H](O[C@H]2C)[C@@H]3OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CB-0003 and CAS 945628-66-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite or the named structural feature represented by this product.