Phosphorus Reagents
Tetramethyl methylenebis(phosphonate)
Quick view. The tetramethyl ester of methylenebisphosphonic acid, used as a compact bisphosphonate building block. CAS 16001-93-7. Catalog target purity: Specification on request.

Product profile
Tetramethyl methylenebis(phosphonate) is classified as specialty phosphorus reagent or intermediate (Formula C5H14O6P2; molecular weight 232.11).
Tetramethyl methylenebis(phosphonate) — Preparation of substituted methylenebisphosphonate derivatives.
For Tetramethyl methylenebis(phosphonate), reported solubility: Chloroform (Sparingly), Methanol (Sparingly). Storage: Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 16001-93-7
- TETRAMETHYL METHYLENEDIPHOSPHONATE
- Tetramethyl methylenediphosphonatedisc 6/01
- (Dimethoxy-phosphorylmethyl)-phosphonicaciddimethylester
Useful catalog search terms
- CAS 16001-93-7
- Specialty phosphorus reagent or intermediate
- Phosphorus Reagents
Physicochemical data
| Form | Oil |
|---|---|
| Color | Colourless |
| SMILES | C(P(=O)(OC)OC)P(=O)(OC)OC |
| InChI | InChI=1S/C5H14O6P2/c1-8-12(6,9-2)5-13(7,10-3)11-4/h5H2,1-4H3 |
| InChIKey | XAVFZUKFLWOSOS-UHFFFAOYSA-N |
| Boiling point | 152-154°C 2,5mm |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Precursor to partially or fully dealkylated phosphonic-acid products.
Related products
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BX-PR-0003Tetraethyl methylenebis(phosphonate)
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BX-PR-0004TetraPOM methylenebis(phosphonate)
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BX-PR-0005Bis(tributylammonium) pyrophosphate (50% wt in ACN)
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Frequently asked questions
Can the package size for Tetramethyl methylenebis(phosphonate) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PR-0006 and CAS 16001-93-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
