Halogenated Nucleosides
2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine
Quick view. We supply 2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 15379-29-0. Catalog target purity: Specification on request.
Product profile
2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H9FN2O4; molecular weight 228.18).
2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 5-Fluoro-4-hydroxy-1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2(1H)-one
- 2’,3’-Dideoxy-2’,3’-didehydro-5-fluoro-uridine,, FddddU
Useful catalog search terms
- CAS 15379-29-0
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H9FN2O4/c10-6-3-12(9(15)11-8(6)14)7-2-1-5(4-13)16-7/h1-3,5,7,13H,4H2,(H,11,14,15) |
|---|---|
| InChIKey | SHVSSJHFEDAZCZ-UHFFFAOYSA-N |
| SMILES | O=c1nc(O)c(F)cn1C1C=CC(CO)O1 |
| Density | 1.57±0.1 g/cm3(Predicted) |
| pKa | 7.55±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0172 and CAS 15379-29-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.