Halogenated Nucleosides
2',3'-Dideoxy-3'-fluorouridine
Quick view. We supply 2',3'-Dideoxy-3'-fluorouridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 41107-56-6. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2',3'-Dideoxy-3'-fluorouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11FN2O4; molecular weight 230.19).
2',3'-Dideoxy-3'-fluorouridine — 2'',3''-Dideoxy-3''-fluorouridine is a reactant used in the synthesis of 5''-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase.
For 2',3'-Dideoxy-3'-fluorouridine, reported solubility: Aqueous Base (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly), Water. Storage: -20°C Freezer.
Names and search terms
Confirmed or normalized name variants
- Fddurd
- 3'-FLUORO-2',3'-DIDEOXYURIDINE
- URIDINE, 2',3'-DIDEOXY-3'-FLUORO-
- 1-(2,3-DIDEOXY-3-FLUORO-BETA-D-RIBOFURANOSYL)URACIL
- 5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine)-3-fluoro-2-hydroxymethyltetrahydrofuran
Useful catalog search terms
- CAS 41107-56-6
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| Melting point | 184-188 °C(lit.) |
|---|---|
| Density | 1.50±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Solid |
| Color | White to Off-White |
| SMILES | OC[C@H]1O[C@H](C[C@@H]1F)N2C=CC(=O)NC2=O |
| InChI | 1S/C9H11FN2O4/c10-5-3-8(16-6(5)4-13)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4H2,(H,11,14,15)/t5-,6+,8+/m0/s |
| InChIKey | BKIUEHLYJFLWPK-SHYZEUOFSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2',3'-Dideoxy-3'-fluorouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-3'-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-3'-fluorouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0229 and CAS 41107-56-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2',3'-Dideoxy-3'-fluorouridine or the named structural feature represented by this product.
- Validation of a high-performance liquid chromatographic-mass spectrometric method for the measurement of 5-chloro-2',3'-dideoxy-3' -fluorouridine (935U83) in human plasma. (1996)
- Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate. (1984)
- Safety and pharmacokinetics of 5-chloro-2',3'-dideoxy-3'-fluorouridine (935U83) following oral administration of escalating single doses in human immunodeficiency virus-infected adults. (1996)
- 5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile. (1994)
- PURIFICATION OF FLUORONUCLEOSIDES (1994)