Halogenated Nucleosides
2',5'-Dideoxy-5'-iodouridine
Quick view. We supply 2',5'-Dideoxy-5'-iodouridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 58510-66-0. Catalog target purity: Specification on request.
Product profile
2',5'-Dideoxy-5'-iodouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11IN2O4; molecular weight 338.1).
2',5'-Dideoxy-5'-iodouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',5'-Dideoxy-5'-iodouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Uridine, 2',5'-dideoxy-5'-iodo-
Useful catalog search terms
- CAS 58510-66-0
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H11IN2O4/c10-4-6-5(13)3-8(16-6)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4H2,(H,11,14,15)/t5-,6+,8+/m0/s |
|---|---|
| InChIKey | JYWLLSHCWALPBJ-SHYZEUOFSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CI)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',5'-Dideoxy-5'-iodouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',5'-Dideoxy-5'-iodouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0124 and CAS 58510-66-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.