2'-FANA Nucleosides
2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine
Quick view. We supply 2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 69123-95-1. Catalog target purity: Specification on request.
Product profile
2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H10F2N2O5; molecular weight 264.183).
2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 1-(2-Deoxy-2-fluoropentofuranosyl)-5-fluoro-4-hydroxypyrimidin-2(1H)-one
- 2',5-difluoro-2'-deoxy-1-arabinosyluracil
- 5-Fluoro-2'-fluoro-2'-deoxy-beta-D-arabinouridine
- 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-
- 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione
- 2,4(1H,3H)-PYRIMIDINEDIONE,1-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)-5-FLUORO-
Useful catalog search terms
- CAS 69123-95-1
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-FANA Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C9H10F2N2O5/c10-3-1-13(9(17)12-7(3)16)8-5(11)6(15)4(2-14)18-8/h,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m0/s |
| InChIKey | QURNODSOJKSTBM-GCJQMDKQSA-N |
| SMILES | C1=C(C(=O)NC(=O)N1[C@@H]2[C@@H]([C@H]([C@@H](O2)CO)O)F)F |
| Melting point | 168-170 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) |
| Density | 1.69±0.1 g/cm3(Predicted) |
| pKa | 7.63±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAN-0073 and CAS 69123-95-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine or the named structural feature represented by this product.