Base-protected Nucleosides
2'-F-dG(DMF)
Quick view. We supply 2'-F-dG(DMF) as an N2-dimethylformamidine protected 2'-fluoro deoxyguanosine intermediate for preparing 2'-F guanosine phosphoramidites and modified oligonucleotide building blocks. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%.
Product profile
2'-F-dG(DMF) is classified as nucleoside or protected nucleoside intermediate.
2'-F-dG(DMF) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dG(DMF), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dG(DMF) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Frequently asked questions
Can the package size for 2'-F-dG(DMF) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0005, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.