2'-F Nucleosides
2'-F-dU
Quick view. We supply 2'-F-dU as a 2'-fluoro uridine analog for modified RNA chemistry. CAS 784-71-4. Catalog target purity: Specification on request.
Product profile
2'-F-dU is classified as nucleoside or protected nucleoside intermediate (Formula C9H11FN2O5; molecular weight 246.19).
2'-F-dU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dU, reported solubility: Soluble in methanol. Storage: Inert atmosphere,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 1-(2'-FLUORO-2'-DESOXY-BETA-D-RIBOFURANOSYL)URACIL
- 2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-BETA-D-RIBOFURANOSYL)
- 2'-DEOXY-2'-FLUOROURIDINE
- 2'-FLUORO-2'-DEOXYURIDINE
- 2'-FLUORO-2'-DESOXY-URIDINE
- 2'-FLUORO-D-URIDINE
- 2'-FU
- 2'-FUDR
Useful catalog search terms
- CAS 784-71-4
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Melting point | 147.0 to 153.0 °C |
| Density | 1.63±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O |
| InChI | InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s |
| InChIKey | UIYWFOZZIZEEKJ-XVFCMESISA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-F-dU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0181 and CAS 784-71-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.