LNA Locked Nucleosides
2'-O-4'-C-Locked-5-Me-rC
Quick view. We supply 2'-O-4'-C-Locked-5-Me-rC as a 5-methyl locked cytidine nucleoside intermediate for LNA monomer synthesis and high-affinity oligonucleotide research. CAS 847650-87-7. Catalog target purity: ≥98%.
Product profile
2'-O-4'-C-Locked-5-Me-rC is classified as nucleoside or protected nucleoside intermediate (molecular weight 269.25).
2'-O-4'-C-Locked-5-Me-rC can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-4'-C-Locked-5-Me-rC, storage: 2-8°C, protect from light. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- LNA-methyl-C
- 5-Methyl-2'-O,4'-C-methylenecytidine
- 5-Methyl-2’-O,4’-C-methylenecytidine, LNA-5MeC
Useful catalog search terms
- CAS 847650-87-7
- Nucleoside or protected nucleoside intermediate
- conformationally locked sugar
- LNA Locked Nucleosides
Physicochemical data
| Key chemistry motifs | conformationally locked sugar |
|---|---|
| pKa | 13.22±0.60(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O-4'-C-Locked-5-Me-rC or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 2'-O-4'-C-Locked-5-Me-rC be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0002 and CAS 847650-87-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-4'-C-Locked-5-Me-rC or the named structural feature represented by this product.