2'-O-Me Nucleosides
2'-O-Me-rC
Quick view. We supply 2'-O-Me-rC as a 2'-O-methyl cytidine nucleoside for RNA modification and monomer synthesis. CAS 2140-72-9. Catalog target purity: Specification on request.
Product profile
2'-O-Me-rC is classified as nucleoside or protected nucleoside intermediate (Formula C10H15N3O5; molecular weight 257.24).
2'-O-Me-rC can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-Me-rC, reported solubility: Soluble in DMSO. Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- 2'-O-METHYLCYTIDINE
- 2'-O-Methylcytidineanhydrous
- 2'-O-Methyl-D-cytidine
- 2'-O-Methylcytidine
Useful catalog search terms
- CAS 2140-72-9
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Melting point | 252-253 C |
| Boiling point | 506.0±60.0 °C(Predicted) |
| Density | 1.68±0.1 g/cm3(Predicted) |
| pKa | 13.37±0.70(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OC)[C@@H]1O |
| InChI | InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s |
| InChIKey | RFCQJGFZUQFYRF-ZOQUXTDFSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rC or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-rC be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0175 and CAS 2140-72-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.