2'-O-NMA Phosphoramidites
5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]uridine-3'-CE phosphoramidite
Quick view. A 5-methyluridine building block bearing a 5'-O-DMTr group, a 2'-O-[2-(methylamino)-2-oxoethyl] substituent, and a 3'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 1025783-16-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]uridine-3'-CE phosphoramidite](/structures/84c452c3bca9841d.svg)
Product profile
5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]uridine-3'-CE phosphoramidite is classified as 2'-o-nma phosphoramidites (Formula C43H54N5O10P; molecular weight 831.90).
5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]uridine-3'-CE phosphoramidite — Identity-defined 2'-O-NMA-5-Me-U phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]uridine-3'-CE phosphoramidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2'-O-NMA-5-Me-U phosphoramidite
- 5'-O-DMT-2'-O-NMA-5-Me-U-3'-CE phosphoramidite
- 2'-O-NMA-T amidite
- 5'-O-DMTr-2'-O-(N-methylaminocarbonylmethyl)-5-methyluridine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 1025783-16-7
Physicochemical data
| InChIKey | FYNKMLIMLHVWST-FMMLDEGOSA-N |
|---|---|
| Nucleoside | 5-Methyluridine |
| Base protection | None |
| 5' protection | DMTr |
| 2'-Modification | O-[2-(methylamino)-2-oxoethyl] (NMA) |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| PubChem CID | 177789600 |
| InChI | InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-38-36(57-41(39(38)54-27-37(49)45-6)47-25-30(5)40(50)46-42(47)51)26-55-43(31-13-10-9-11-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h9-11,13-22,25,28-29,36,38-39,41H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38-,39-,41-,59?/m1/s1 |
| SMILES | CNC(=O)CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1cc(C)c(=O)[nH]c1=O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]uridine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
N6-Benzoyl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]adenosine-3'-CE phosphoramidite
2'-O-NMA Phosphoramidites · CAS: 1025783-20-3
BX-2ONP-0002N2-Isobutyryl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]guanosine-3'-CE phosphoramidite
2'-O-NMA Phosphoramidites · CAS: 1025783-22-5
BX-2ONP-0003N4-Benzoyl-5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]cytidine-3'-CE phosphoramidite
2'-O-NMA Phosphoramidites · CAS: 1025783-18-9
Frequently asked questions
Can the package size for 5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]uridine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2ONP-0004 and CAS 1025783-16-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-NMA Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.