2'-O-Me Phosphoramidites
2'-OMe-5-Me-U Phosphoramidite
Quick view. We supply 2'-OMe-5-Me-U Phosphoramidite as a 2'-O-methyl 5-methyluridine/thymidine analog amidite for modified RNA and ASO synthesis. CAS 153631-20-0. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-OMe-5-Me-U Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C41H51N4O9P; molecular weight 774.84).
2'-OMe-5-Me-U Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 2'-OMe-5-Me-U Phosphoramidite, form: Solid.
Names and search terms
Confirmed or normalized name variants
- 2'-O-METHYL-5-METHYL-U CEP
- DMT-2'-OME-dU(Bz)-CE-Phosphoramidite
- 2'-O-Methyl-5-Methyl-U CE phosphoramidite
- 5'-O-DMT-5-methyl-2'-O-methyluridine 3'-CE phosphoramidite
- 5'-O-DMT-2'-O-methyl-5-methyluridine 3'-CE phosphoramidite
- 5’-O-DMTr-2’-O-methyl-5-methyluridine 3’-CED phosphoramidite
Useful catalog search terms
- CAS 153631-20-0
- Protected oligonucleotide phosphoramidite building block
- 2'-O-methyl modification
- phosphoramidite coupling group
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | Off-white to yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Methyl-5-methyl-U CEP is a uridine, can be used for synthesis nucleic acid.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-OMe-5-Me-U Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
4'-O-CH2-phosphate methyl ester-2'-O-Me-rU-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2197181-94-3
BX-2OMP-00164'-O-CH₂-phosphate monomethyl ester-2'-O-Me-rU-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00175'-CH₂-phosphate methyl ester-2'-O-Me-U-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00185'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00195'-POM-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2419895-65-9
BX-2OMP-00205'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for 2'-OMe-5-Me-U Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0056 and CAS 153631-20-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.