Cyclic Dinucleotides
3',3'-cGAMP diammonium salt
Quick view. We supply 3',3'-cGAMP diammonium salt for cyclic GMP-AMP response and analytical comparison studies. CAS 849214-04-6. Catalog target purity: ≥98%.
Product profile
3',3'-cGAMP diammonium salt is classified as cyclic dinucleotide second messenger or analog (Formula C20H24N10O13P2; molecular weight 674.41).
3',3'-cGAMP diammonium salt — c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.
For 3',3'-cGAMP diammonium salt, reported solubility: Soluble in water; confirm lot-specific concentration limits. Storage: −20 °C.
Names and search terms
Confirmed or normalized name variants
- cGAMP diammonium
- 3'3'-cGAMP diammonium
- 3',3'-cyclic GMP-AMP diammonium
- cGAMP
- c-GpAp
- di-GAMP
- di-cGAMP
- 3'3'-cGAMP
Useful catalog search terms
- CAS 849214-04-6
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Purity basis | Research-grade target; the lot-specific CoA reports the release result and analytical method. |
| Linkage | Two 3'-5' phosphodiester linkages |
| Counterion | Diammonium |
| Supply form | Dry salt |
| Boiling point | 1159.9±75.0 °C(Predicted) |
| Density | 2.61±0.1 g/cm3(Predicted) |
| pKa | 0.96±0.70(Predicted) |
| Form | powder |
| Color | white to beige |
| SMILES | Nc1[nH]c(=O)c2c(n(cn2)[C@@H]2O[C@@H]3COP(=O)(O[C@@H]4[C@@H](COP(=O)(O[C@H]3[C@H]2O)O)O[C@@H](n2c3c(nc2)c(N)ncn3)[C@@H]4O)O)n |
| InChIKey | RFCBNSCSPXMEBK-VBLLSAMJNA-N |
| Identity note | The catalog item is the diammonium salt; CAS is the corresponding cGAMP identity. Confirm counterion and hydration state on the current specification. |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 3',3'-cGAMP diammonium salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe 3',3'-cGAMP diammonium salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3',3'-cGAMP diammonium salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0012 and CAS 849214-04-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response