Modified Nucleosides
3',5'-Bis-O-(t-butyldimethylsilyl)thymidine
Quick view. We supply 3',5'-Bis-O-(t-butyldimethylsilyl)thymidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 40733-26-4. Catalog target purity: Specification on request.
Product profile
3',5'-Bis-O-(t-butyldimethylsilyl)thymidine is classified as nucleoside or protected nucleoside intermediate (Formula C22H42N2O5Si; molecular weight 470.75).
3',5'-Bis-O-(t-butyldimethylsilyl)thymidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3',5'-Bis-O-(t-butyldimethylsilyl)thymidine, reported solubility: Ethyl Acetate. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- Thymidine, 3′,5′-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-
- 3',5'-Bis-O-[(1,1-dimethylethyl)dimethylsilyl]thymidine
Useful catalog search terms
- CAS 40733-26-4
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C22H42N2O5Si2/c1-15-13-24(20(26)23-19(15)25)18-12-16(29-31(10,11)22(5,6)7)17(28-18)14-27-30(8,9)21(2,3)4/h13,16-18H,12,14H2,1-11H3,(H,23,25,26)/t16-,17+,18+/m0/s |
|---|---|
| InChIKey | DDLOCFSZSYGOPG-RCCFBDPRSA-N |
| SMILES | Cc1cn([C@H]2C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](CO[Si](C)(C)C(C)(C)C)O2)c(=O)nc1O |
| Form | Solid |
| Color | White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 3',5'-Bis-O-(t-butyldimethylsilyl)thymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0527 and CAS 40733-26-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.