Modified Nucleosides
3',5'-Bis-O-(tert-butyldimethylsilyl)thymidine
Quick view. A thymidine derivative with the 3'- and 5'-oxygen atoms protected as tert-butyldimethylsilyl ethers, CAS 40733-26-4. CAS 40733-26-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3',5'-Bis-O-(tert-butyldimethylsilyl)thymidine is classified as bis-silyl-protected thymidine (Formula C22H42N2O5Si2; molecular weight 470.75 g/mol).
3',5'-Bis-O-(tert-butyldimethylsilyl)thymidine — A 3',5'-O-protected thymidine intermediate for research in nucleoside synthesis and functionalization.
For 3',5'-Bis-O-(tert-butyldimethylsilyl)thymidine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3',5'-Di-O-TBDMS thymidine
- 3',5'-Bis-O-[(1,1-dimethylethyl)dimethylsilyl]thymidine
- Thymidine, 3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-
Useful catalog search terms
- 40733-26-4
- C22H42N2O5Si2
- PubChem CID 10459624
- protected thymidine
Physicochemical data
| PubChem CID | 10459624 |
|---|---|
| InChIKey | DDLOCFSZSYGOPG-RCCFBDPRSA-N |
| Nucleoside core | Thymidine |
| Protecting groups | 3'-O-TBDMS and 5'-O-TBDMS |
| InChI | InChI=1S/C22H42N2O5Si2/c1-15-13-24(20(26)23-19(15)25)18-12-16(29-31(10,11)22(5,6)7)17(28-18)14-27-30(8,9)21(2,3)4/h13,16-18H,12,14H2,1-11H3,(H,23,25,26)/t16-,17+,18+/m0/s1 |
| SMILES | Cc1cn([C@H]2C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](CO[Si](C)(C)C(C)(C)C)O2)c(=O)nc1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Frequently asked questions
Can the package size for 3',5'-Bis-O-(tert-butyldimethylsilyl)thymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0527 and CAS 40733-26-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.