Modified Nucleosides
3'-O-(2-Methoxyethyl)adenosine
Quick view. We supply 3'-O-(2-Methoxyethyl)adenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 303197-30-0. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
3'-O-(2-Methoxyethyl)adenosine is classified as nucleoside or protected nucleoside intermediate (Formula C13H19N5O5; molecular weight 325.32).
3'-O-(2-Methoxyethyl)adenosine — 3''-O-(2-Methoxyethyl)adenosine is an adenosine derivative as building blocks for cross-linking oligonucleotides.
For 3'-O-(2-Methoxyethyl)adenosine, reported solubility: DCM.
Names and search terms
Confirmed or normalized name variants
- 3'-MOE-Adenosine
- -O-(2-Methoxyethyl)adenosine
Useful catalog search terms
- CAS 303197-30-0
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Boiling point | 639.0±65.0 °C(Predicted) |
| Density | 1.70±0.1 g/cm3(Predicted) |
| pKa | 12.97±0.70(Predicted) |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1OCCOC |
| InChI | InChI=1S/C13H19N5O5/c1-21-2-3-22-10-7(4-19)23-13(9(10)20)18-6-17-8-11(14)15-5-16-12(8)18/h5-7,9-10,13,19-20H,2-4H2,1H3,(H2,14,15,16)/t7-,9-,10-,13-/m1/s |
| InChIKey | RHVMAYVXDAXYHR-QYVSTXNMSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 3'-O-(2-Methoxyethyl)adenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(2-Methoxyethyl)adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-(2-Methoxyethyl)adenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0797 and CAS 303197-30-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.