Modified Nucleosides
5-Carboxymethyl-2-thiouridine
Quick view. We supply 5-Carboxymethyl-2-thiouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 58479-77-9. Catalog target purity: Specification on request.
Product profile
5-Carboxymethyl-2-thiouridine is classified as nucleoside or protected nucleoside intermediate (Formula C11H14N2O7S; molecular weight 318.303).
5-Carboxymethyl-2-thiouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-Carboxymethyl-2-thiouridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2-Thio-5-carboxymethyluridine
- 5-Carboxymethyl-2-thiouridine, 2-thiouridine 5-acetic acid
Useful catalog search terms
- CAS 58479-77-9
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C11H14N2O7S/c14-3-5-7(17)8(18)10(20-5)13-2-4(1-6(15)16)9(19)12-11(13)21/h,5,7-8,10,14,17-18H,1,3H2,(H,15,16)(H,12,19,21)/t5-,7-,8-,10-/m1/s |
|---|---|
| InChIKey | MSGFOEBMIJOVCL-VPCXQMTMSA-N |
| SMILES | O=C(O)Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=S)nc1O |
| Density | 1.78±0.1 g/cm3(Predicted) |
| pKa | 3.82±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5-Carboxymethyl-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Carboxymethyl-2-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0600 and CAS 58479-77-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.