Halogenated Nucleosides
5-Chloro-2'-deoxyuridine
Quick view. We supply 5-Chloro-2'-deoxyuridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 50-90-8. Catalog target purity: Specification on request.
Product profile
5-Chloro-2'-deoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11ClN2O5; molecular weight 262.65).
5-Chloro-2'-deoxyuridine — 5-Chloro-2′-deoxyuridine (CldU) is used as a thymidine analog to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a…
For 5-Chloro-2'-deoxyuridine, reported solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly). Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- 5-Chloro-1-(2-deoxypentofuranosyl)-4-hydroxypyrimidin-2(1H)-one
- CldU
- CLUDR
- NSC-371331, CDC
- Chlorodeoxyuridine
- 5-Chlorodeoxyuridin
- 5-CHLORODEOXYURIDINE
- 5-CHLORODESOXYURIDINE
Useful catalog search terms
- CAS 50-90-8
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s |
|---|---|
| InChIKey | NJCXGFKPQSFZIB-RRKCRQDMSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(Cl)C(=O)NC2=O)C[C@@H]1O |
| Melting point | 176-179°C |
| Density | 1.5507 (rough estimate) |
| pKa | 7.73±0.10(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Chloro-2'-deoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5-Chloro-2'-deoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0121 and CAS 50-90-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.