2'-O-MOE Nucleosides
5'-O-DMTr-2'-O-MOE-N4-acetylcytidine
Quick view. A protected modified cytidine bearing 5'-O-dimethoxytrityl, 2'-O-(2-methoxyethyl) and N4-acetyl groups, CAS 1345716-47-3. CAS 1345716-47-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-O-MOE-N4-acetylcytidine is classified as 2'-o-moe nucleosides (Formula C35H39N3O9; molecular weight 645.71).
5'-O-DMTr-2'-O-MOE-N4-acetylcytidine — Protected modified cytidine building block for oligonucleotide synthesis.
For 5'-O-DMTr-2'-O-MOE-N4-acetylcytidine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-N4-Ac-2'-O-(2-methoxyethyl)cytidine
- 5'-O-DMTr-2'-O-MOE-Cytidine(N-Ac)
Useful catalog search terms
- CAS 1345716-47-3
- BOC Sciences BRP-00744
- ChemGenes India CGIDPM-1121
- RLHWWSNMWZITIE-WXQJYUTRSA-N
Physicochemical data
| Systematic name | N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide |
|---|---|
| InChIKey | RLHWWSNMWZITIE-WXQJYUTRSA-N |
| Canonical SMILES | COCCO[C@@H]1[C@H](O)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1ccc(NC(C)=O)nc1=O |
| 5'-hydroxyl protection | Dimethoxytrityl (DMTr) |
| 2'-substitution | O-(2-methoxyethyl) (MOE) |
| Nucleobase protection | N4-acetyl cytidine |
| InChI | InChI=1S/C35H39N3O9/c1-23(39)36-30-18-19-38(34(41)37-30)33-32(45-21-20-42-2)31(40)29(47-33)22-46-35(24-8-6-5-7-9-24,25-10-14-27(43-3)15-11-25)26-12-16-28(44-4)17-13-26/h5-19,29,31-33,40H,20-22H2,1-4H3,(H,36,37,39,41)/t29-,31-,32-,33-/m1/s1 |
| SMILES | COCCO[C@@H]1[C@H](O)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1ccc(NC(C)=O)nc1=O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-N4-acetylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-MOE-N4-acetylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0003 and CAS 1345716-47-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.