2'-O-Me Phosphoramidites
5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite
Quick view. 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite is a 2'-O-methyl adenosine analog amidite with a masked vinyl phosphonate 5'-motif and 6-deamino aryl ester modification. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Product profile
5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block.
5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- 2-cyanoethyl phosphoramidite
Useful catalog search terms
- Protected oligonucleotide phosphoramidite building block
- 2'-O-methyl modification
- amine functionality
- phosphoramidite coupling group
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification; amine functionality; phosphoramidite coupling group |
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Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-2OMP-00175'-CH₂-phosphate methyl ester-2'-O-Me-U-3'-CE-Phosphoramidite
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BX-2OMP-00195'-POM-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
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BX-2OMP-00205'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
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BX-2OMP-00215'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0018, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.