GalNAc
Ac4GalNAz
Quick view. We supply Ac4GalNAz for glycochemistry and carbohydrate research. The released purity specification and lot documentation are confirmed with our technical team before order. CAS 653600-56-7. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
Ac4GalNAz is classified as galnac ligand, linker or conjugation intermediate (Formula C16H22N4O10; molecular weight 430.37).
Ac4GalNAz can be evaluated in ligand, linker and conjugation-route development for oligonucleotide delivery research.
For Ac4GalNAz, reported solubility: DMSO, DMF, DCM, THF, Chloroform. Storage: -20°C.
Names and search terms
Confirmed or normalized name variants
- N-Azidoacetylgalactosamine, Acylated
- N-Azidoacetylgalactosamine-tetraacylated
- 1,3,4,6-Tetra-O-acetyl-N-azidoacetylgalactosamine
- N-azidoacetylgalactosamine-tetraacylated (Ac4GaINAz)
- N-N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz)
- N-azidoacetylgalactosamine-tetraacylated (Ac4GaINAz) USP/EP/BP
- 1,3,4,6-Tetra-O-acetyl-2-[(azidoacetyl)amino]-2-deoxy-β-D-galactopyranos
- 2-[(2-Azidoacetyl) amino] -2-deoxy-1,3,4,6- tetra-O-acetyl-D-galac- topyranose
Useful catalog search terms
- CAS 653600-56-7
- GalNAc ligand, linker or conjugation intermediate
- GalNAc ligand motif
- GalNAc
Physicochemical data
| Key chemistry motifs | GalNAc ligand motif |
|---|---|
| Form | powder or crystals |
| Color | White to off-white |
| SMILES | O([C@H]1[C@H]([C@@H](COC(=O)C)OC(OC(=O)C)[C@@H]1NC(=O)CN=[N+]=[N-])OC(=O)C)C(=O)C |&1:1,2,3,15,r| |
| InChI | 1S/C16H22N4O10/c1-7(21)26-6-11-14(27-8(2)22)15(28-9(3)23)13(16(30-11)29-10(4)24)19-12(25)5-18-20-17/h11,13-16H,5-6H2,1-4H3,(H,19,25)/t11?,13?,14-,15?,16+/m0/s |
| InChIKey | HGMISDAXLUIXKM-FECVBEAVNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- N -Azidoacetylgalactosamine-tetraacylated (Ac 4 GalNAz) provides the first part of a simple and robust two-step technique that helps identify and characterize cell surface sialic acid-containing glycoproteins. The azide-modified protein can be detected by reaction with alkynes. For example alkynes labeled with a fluorescent probe or a biotin can be used. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.
- Typical studies compare linker length, valency, attachment chemistry, purification strategy and analytical identity.
- The material may also support conjugate-reference or impurity-standard preparation.
Product-specific evaluation notes
Potential advantages
- A defined GalNAc intermediate helps decouple ligand-linker optimization from sequence optimization.
Method limitations
- In-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
These points describe Ac4GalNAz or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for Ac4GalNAz be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-GALN-0048 and CAS 653600-56-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the GalNAc product family and its named chemistry.