Cyclic Dinucleotides
c-di-AMP
Quick view. We supply c-di-AMP for bacterial nucleotide signaling, host-response and second-messenger research. CAS 54447-84-6. Catalog target purity: ≥99%.
Product profile
c-di-AMP is classified as cyclic dinucleotide second messenger or analog (Formula C20H24N10O12P2; molecular weight 658.42).
c-di-AMP can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For c-di-AMP, reported solubility: Aqueous solubility is salt-form and concentration dependent; confirm the current lot specification before preparing a stock. Storage: Store sealed and dry; use the lot-specific CoA for the recommended temperature and hold time.
Names and search terms
Confirmed or normalized name variants
- Cyclic di-AMP
- Cyclic diadenosine monophosphate
- c-di-adenosine monophosphate
- di-AMP
- di-cAMP
- Cyclic diadenylate
- Cyclic di-3',5'-adenylate
- c-di-AMP (Cyclic diadenylate
Useful catalog search terms
- CAS 54447-84-6
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Purity basis | Research-grade target; the lot-specific CoA reports the release result and analytical method. |
| Supply form | Dry research material |
| InChI | InChI=1S/C20H24N10O12P2/c21-15-9-17(25-3-23-15)29(5-27-9)19-11(31)13-7(39-19)1-37-43(33,34)42-14-8(2-38-44(35,36)41-13)40-20(12(14)32)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-32H,1-2H2,(H,33,34)(H,35,36)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s |
| InChIKey | PDXMFTWFFKBFIN-XPWFQUROSA-N |
| SMILES | NC1=NC=NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP(OC[C@@H]4[C@@H](O5)[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O4)(O)=O)[C@H]3COP5(O)=O.C |
| Boiling point | 1096.7±75.0 °C(Predicted) |
| Density | 2.52±0.1 g/cm3(Predicted) |
| pKa | 0.96±0.70(Predicted) |
| Form | powder |
| Color | white to beige |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe c-di-AMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for c-di-AMP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0013 and CAS 54447-84-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response
