2'-Fluoro Phosphoramidites
DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite as the acetyl-protected CE form of 2'-F cytidine for oligonucleotide synthesis. CAS 159414-99-0. Catalog target purity: Specification on request.
Product profile
DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C41H49FN5O8P; molecular weight 789.83).
DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite — Dmt-2''-f-dc(ac) amidite (CAS# 159414-99-0) is a nucleotide used in the preparation of cell-penetrating and neurotargeting dendritic siRNA nanostructures.
For DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite, reported solubility: DMSO: 100 mg/mL (126.61 mM). Storage: Sealed in dry,Store in freezer, under -20°C.
Names and search terms
Confirmed or normalized name variants
- 2'-Fluoro-dC CEP
- 2'-F-Ac-dC Phosphoramidtie
- Ac-2'-F-dC Phosphoramidite
- 2'-F-Ac-dC Phosphoramidite
- 2’-F-rC(N-Ac) Phosphoramidite
- 5'-O-DMT-2'-F-dC(N-Ac)-3'-CEDPA
- DMT-2'-F-dC(Ac)-CE Phosphoramidite
- DMT-2′Fluoro-dC(ac) Phosphoramidite
Useful catalog search terms
- CAS 159414-99-0
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-fluoro modification
- phosphoramidite coupling group
- 2'-F-dC(Ac) Phosphoramidite
- BX-2FP-0019
- 2'-Fluoro Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification; phosphoramidite coupling group |
|---|---|
| Form | powder |
| Color | white to off-white |
| SMILES | N1([C@@H]2O[C@@H]([C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@H]2F)COC(C2=CC=CC=C2)(C2=CC=C(OC)C=C2)C2C=CC(OC)=CC=2)C=CC(=NC1=O)NC(C)=O |&1:1,3,4,19,r| |
| InChIKey | CNFKJHKDSRXNFL-XSLLURDHNA-N |
| InChI | InChI=1S/C41H49FN5O8P/c1-27(2)47(28(3)4)56(53-25-11-23-43)55-38-35(54-39(37(38)42)46-24-22-36(44-29(5)48)45-40(46)49)26-52-41(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,44,45,48,49)/t35-,37-,38-,39-,56?/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0025 and CAS 159414-99-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry.