2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite
Quick view. We supply DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite as a benzoyl-protected 2'-O-methyl cytidine amidite for RNA/ASO synthesis. CAS 110764-78-8. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H54N5O9P; molecular weight 863.93).
DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite, reported solubility: DMSO: 100 mg/mL (115.75 mM; Need ultrasonic). Storage: 4°C, protect from light.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-C amidite
- Bz-2'-OMe-C Phosphoramidite
- 2'-OMe-Bz-C Phosphoramidite
- 2'-O-Me-C(Bz)) Phosphoramidite
- DMT-2'-O-Me-dC(Bz) Phosphoramidite
- 5'-O-DMTr-2'-O-Me-C(Bz)-CE Phosphoramidite
- N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite
- N4-Bz-5'-O-DMTr- 2'-O-Me-cytidine-3'-CED-phosphoramidite
Useful catalog search terms
- CAS 110764-78-8
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-methyl modification
- phosphoramidite coupling group
- 2'-OMe-C(Bz) Phosphoramidite
- BX-2OMP-0054
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(=O)C3=CC=CC=C3)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,44,47,r| |
| InChIKey | JFFSFQRVIPPCBC-HDUGIDANNA-N |
| InChI | InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(59-30-14-28-48)61-42-40(60-45(43(42)57-7)51-29-27-41(50-46(51)54)49-44(53)34-15-10-8-11-16-34)31-58-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3,(H,49,50,53,54)/t40-,42-,43-,45-,62?/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0072 and CAS 110764-78-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.