2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite as a DMF-protected 2'-O-methyl guanosine amidite for RNA/ASO synthesis. CAS 128219-77-2. Catalog target purity: ≥98%.
Product profile
DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C44H55N8O8P; molecular weight 854.93).
DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Methyl-N2-dimethylformamide-5'-O-DMT-Guanosine-3'-CE-Phosphoramidite
- DMT-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite
- DMTr-2'-O-Me-rG(dmf)-3'-2-cyanoethyl phosphoramidite
- 2'-OMe-G(dmf) Phosphoramidite
- BX-2OMP-0052
Useful catalog search terms
- CAS 128219-77-2
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-methyl modification
- phosphoramidite coupling group
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification; phosphoramidite coupling group |
|---|---|
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)/N=C/N(C)C)=O)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,43,46,r| |
| InChIKey | ZGDBCILCTOHNAB-VXLKOJDKNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-OMe-dmf-G-CE-Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0035 and CAS 128219-77-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.