2'-O-Me Phosphoramidites
5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N2-isobutyrylguanosine-3'-CE phosphoramidite
Quick view. An S-5'-C-methyl, 2'-O-methyl, N2-isobutyryl guanosine CE phosphoramidite for oligonucleotide synthesis research. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N2-isobutyrylguanosine-3'-CE phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C46H58N7O9P; molecular weight 883.98).
5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N2-isobutyrylguanosine-3'-CE phosphoramidite — Protected S-5'-C-methyl 2'-O-methyl guanosine phosphoramidite building block for oligonucleotide synthesis research.
For 5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N2-isobutyrylguanosine-3'-CE phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- DMTr-S-5-C-Me-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
Physicochemical data
| Nucleoside identity | N2-isobutyryl-S-5'-C-methyl-2'-O-methylguanosine |
|---|---|
| 5' protection | 5'-O-DMTr |
| Coupling group | 3'-CE phosphoramidite |
| Phosphorus stereochemistry | Unspecified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N2-isobutyrylguanosine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2OMP-0020Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-0021Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for 5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N2-isobutyrylguanosine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0045, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.