cEt-BNA
DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite as a constrained ethyl BNA phosphoramidite for high-affinity therapeutic oligonucleotide synthesis. CAS 1197033-17-2. Catalog target purity: Specification on request.
Product profile
DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C49H56N5O9P; molecular weight 889.97).
DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite — 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a…
For DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite, form: Solid.
Names and search terms
Confirmed or normalized name variants
- S-cEt-C phosphoramidite
- 5'-O-DMTr-cEt-BNA-N-Bz-Me-Cytidine-CEP
- 5'-ODMT cEt N-Bz 5-Me C Phosphoramidite
- DMT-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite
- DMTr-S-cEt-5-Me-rC(Bz)-3'-2-cyanoethyl phosphoramidite
Useful catalog search terms
- CAS 1197033-17-2
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- conformationally locked sugar
- phosphoramidite coupling group
- cEt-BNA
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| InChI | InChI=1S/C49H56N5O9P/c1-32(2)54(33(3)4)64(60-29-15-28-50)63-43-42-46(53-30-34(5)44(52-47(53)56)51-45(55)36-16-11-9-12-17-36)62-48(43,35(6)61-42)31-59-49(37-18-13-10-14-19-37,38-20-24-40(57-7)25-21-38)39-22-26-41(58-8)27-23-39/h9-14,16-27,30,32-33,35,42-43,46H,15,29,31H2,1-8H3,(H,51,52,55,56)/t35-,42+,43-,46+,48-,64?/m0/s |
| InChIKey | BDTXILPCBUAYPJ-USFFSJIASA-N |
| SMILES | COc1ccc(C(OC[C@]23O[C@@H](n4cc(C)c(=NC(=O)c5ccccc5)nc4O)[C@H](O[C@H]2C)[C@@H]3OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CB-0002 and CAS 1197033-17-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-S-cEt-5-Me-rC(Bz)-3'-CE-Phosphoramidite or the named structural feature represented by this product.