2'-O-MOE Nucleosides
N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine
Quick view. We supply N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine as a 2'-O-MOE nucleoside for antisense oligonucleotide monomer and analog synthesis. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine is classified as nucleoside or protected nucleoside intermediate.
N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-methyl modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification; 2'-O-methyl modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-MOE Nucleosides · CAS: 545374-76-3
BX-MN-01672'-O-MOE-5-Me-rC
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BX-MN-01682'-O-MOE-rG
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-MOE-rA
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-MOE-rC
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-MOE-rU
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0024, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.