2'-O-MOE Phosphoramidites
N4-acetyl -5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl Phosphoramidite
Quick view. We supply N4-acetyl -5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl Phosphoramidite as a specialty phosphoramidite building block for solid-phase oligonucleotide synthesis. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
N4-acetyl -5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block.
N4-acetyl -5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For N4-acetyl -5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- Protected oligonucleotide phosphoramidite building block
- 2'-O-MOE modification
- 2'-O-methyl modification
- phosphoramidite coupling group
- 2'-O-MOE Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification; 2'-O-methyl modification; phosphoramidite coupling group |
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Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N4-acetyl -5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N4-acetyl -5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0088, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry.