Modified Nucleosides
O6-Methyldeoxy guanosine
Quick view. We supply O6-Methyldeoxy guanosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 964-21-6. Catalog target purity: Specification on request.
Product profile
O6-Methyldeoxy guanosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O4; molecular weight 281.27).
O6-Methyldeoxy guanosine — O6-Methyl-2’-deoxyguanosine is a ubiquitous DNA lesion formed by xenobiotic carcinogens and endogenous methylating agent, S-adenosyl-L-methionine. A mutagenic adducts formed by a potent tobacco carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
For O6-Methyldeoxy guanosine, reported solubility: Aqueous Base (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly). Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- O(6)-methyl-2'-deoxyguanosine
- 6-O-Methyldeoxyguanosine
- 6-O-METHYL-2'-DEOXYGUANOSINE
- 2'-Deoxy-6-O-methyl-guanosine
- Guanosine, 2'-deoxy-6-O-methyl-
- 2-Amino-6-methoxy-2'-deoxy-6-deaminoadenosine
- 9-(2-Deoxy-β-D-ribofuranosyl)-6-methoxy-9H-purin-2-amine
- 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
Useful catalog search terms
- CAS 964-21-6
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C11H15N5O4/c1-19-10-8-9(14-11(12)15-10)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14,15)/t5-,6+,7+/m0/s |
|---|---|
| InChIKey | BCKDNMPYCIOBTA-RRKCRQDMSA-N |
| SMILES | COC1=NC(=NC2=C1N=CN2[C@H]3C[C@@H]([C@H](O3)CO)O)N |
| Melting point | 109 - 115°C |
| Boiling point | 674.7±65.0 °C(Predicted) |
| Density | 1.84±0.1 g/cm3(Predicted) |
| pKa | 13.76±0.60(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- O6-Methyldeoxy guanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for O6-Methyldeoxy guanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0720 and CAS 964-21-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.