Reverse Phosphoramidites
3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite
Quick view. 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite is a protected 2'-O-methyl adenosine reverse phosphoramidite for research-use oligonucleotide synthesis. CAS 1309448-27-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite is classified as protected 2'-o-methyl adenosine reverse phosphoramidite (Formula C48H54N7O8P; molecular weight 887.97).
3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite — Protected 2'-O-methyl adenosine reverse phosphoramidite building block for research-use solid-phase oligonucleotide synthesis.
For 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-A(Bz)-CE-Reverse Phosphoramidite
- 3'-DMT-2'-OMe-A(Bz)-CE Reverse
Useful catalog search terms
- 1309448-27-8
- C48H54N7O8P
- Reverse Phosphoramidites
- ZTDLWOHDFXTWBU-PSVHYZMASA-N
- PubChem CID 178245187
Physicochemical data
| Key structural motifs | N6-benzoyl protection, 3'-DMT protection, 2'-O-methyl substitution, and a 5'-cyanoethyl N,N-diisopropyl phosphoramidite |
|---|---|
| PubChem CID | 178245187 |
| InChIKey | ZTDLWOHDFXTWBU-PSVHYZMASA-N |
| InChI | InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(60-28-14-27-49)61-29-40-42(43(59-7)47(62-40)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)63-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)OC)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-RP-0013 and CAS 1309448-27-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.