2'-O-MOE Phosphoramidites
DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite is an N2-isobutyryl-protected 2'-O-(2-methoxyethyl) guanosine building block for research-use oligonucleotide synthesis. CAS 251647-55-9. Catalog target purity: ≥98.0%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite is classified as protected 2'-o-moe guanosine phosphoramidite (Formula C47H60N7O10P; molecular weight 914.00).
DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite — N2-isobutyryl-protected 2'-O-(2-methoxyethyl) guanosine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-G(iBu) Phosphoramidite
- DMT-2'-O-MOE-rG(iBu) Phosphoramidite
- N2-Isobutyryl-5'-O-DMTr-2'-O-(2-methoxyethyl)guanosine-3'-CE Phosphoramidite
Useful catalog search terms
- 251647-55-9
- PubChem 136745830
- C47H60N7O10P
Physicochemical data
| Base protection | N2-isobutyryl |
|---|---|
| Ribose modification | 2'-O-(2-methoxyethyl) |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | LADCDGNEBIQAAU-SBCRAQIVSA-N |
| InChI | InChI=1S/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(60-27-26-57-7)40(64-65(62-25-13-24-48)54(31(3)4)32(5)6)38(63-45)28-61-47(33-14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10-12,14-23,29-32,38,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,65?/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC |
| PubChem CID | 136745830 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
DMTr-2'-O-MOE-5-Me-rC(Ac)-3'-CE-Phosphoramidite
2'-O-MOE Phosphoramidites · CAS: N/A
BX-2OMP-0002DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite
2'-O-MOE Phosphoramidites · CAS: 2379296-21-4
BX-2OMP-0003DMTr-2'-O-MOE-5-Me-rC(DMTr)-3'-CE-Phosphoramidite
2'-O-MOE Phosphoramidites · CAS: N/A
BX-2OMP-0004DMTr-2'-O-MOE-5-Me-rC-3'-CE-Phosphoramidite
2'-O-MOE Phosphoramidites · CAS: 251647-56-0
BX-2OMP-0006DMTr-2'-O-MOE-rA(Bz)-3'-(1-hydroxy-N,N-diisopropyl)phosphoramidite
2'-O-MOE Phosphoramidites · CAS: N/A
BX-2OMP-0007DMTr-2'-O-MOE-rA(DMTr)-3'-CE-Phosphoramidite
2'-O-MOE Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0079 and CAS 251647-55-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.