Amino-modified Nucleosides
N2-[(N,N-Dimethylamino)methylene]-N1-methyl-2'-O-methylguanosine
Quick view. Guanosine derivative bearing N2-dimethylaminomethylene, N1-methyl, and 2'-O-methyl substituents. CAS 2305416-07-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Structure of N2-[(N,N-Dimethylamino)methylene]-N1-methyl-2'-O-methylguanosine BX-AMN-0189](/structures/675b1d7a0612cff6.svg)
Product profile
N2-[(N,N-Dimethylamino)methylene]-N1-methyl-2'-O-methylguanosine is classified as amino-modified nucleosides (Formula C15H22N6O5; molecular weight 366.37 g/mol).
N2-[(N,N-Dimethylamino)methylene]-N1-methyl-2'-O-methylguanosine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For N2-[(N,N-Dimethylamino)methylene]-N1-methyl-2'-O-methylguanosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Useful catalog search terms
- 2305416-07-1
Physicochemical data
| PubChem CID | 171975641 |
|---|---|
| Nucleoside scaffold | Guanosine |
| Substitution pattern | N2-dimethylaminomethylene; N1-methyl; 2'-O-methyl |
| IUPAC name | N'-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1-methyl-6-oxopurin-2-yl]-N,N-dimethylmethanimidamide |
| InChIKey | LOSZXLFNDXRZQH-IDTAVKCVSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N2-[(N,N-Dimethylamino)methylene]-N1-methyl-2'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N2-[(N,N-Dimethylamino)methylene]-N1-methyl-2'-O-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0189 and CAS 2305416-07-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.