2'-O-MOE Nucleosides
2'-O-(2-Methoxyethyl)-2-aminoadenosine
Quick view. We supply 2'-O-(2-Methoxyethyl)-2-aminoadenosine as a 2'-O-MOE nucleoside for antisense oligonucleotide monomer and analog synthesis. CAS 256224-13-2. Catalog target purity: Specification on request.
Product profile
2'-O-(2-Methoxyethyl)-2-aminoadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C13H20N6O5; molecular weight 340.34).
2'-O-(2-Methoxyethyl)-2-aminoadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-(2-Methoxyethyl)-2-aminoadenosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2-Amino-2'-O-(2-methoxyethyl)adenosine
- Adenosine, 2-amino-2'-O-(2-methoxyethyl)-
- 5-(2,6-DIAMINOPURIN-9-YL)-2-(HYDROXYMETHYL)-4-(2-METHOXYETHOXY)OXOLAN-3-OL
Useful catalog search terms
- CAS 256224-13-2
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- amine functionality
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification; amine functionality |
|---|---|
| InChI | InChI=1S/C13H20N6O5/c1-22-2-3-23-9-8(21)6(4-20)24-12(9)19-5-16-7-10(14)17-13(15)18-11(7)19/h5-6,8-9,12,20-21H,2-4H2,1H3,(H4,14,15,17,18)/t6-,8-,9-,12-/m1/s |
| InChIKey | ZPWSGIIALWUBNX-WOUKDFQISA-N |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)N)N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-(2-Methoxyethyl)-2-aminoadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-MOE-rI
2'-O-MOE Nucleosides · CAS: 545374-76-3
BX-MN-01672'-O-MOE-5-Me-rC
2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-MOE-rG
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-MOE-rA
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-MOE-rC
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-MOE-rU
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for 2'-O-(2-Methoxyethyl)-2-aminoadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0017 and CAS 256224-13-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.