Base-protected Nucleosides
2'-O-Me-rC(Ac)
Quick view. We supply 2'-O-Me-rC(Ac) as a protected 2'-O-methyl nucleoside precursor for modified RNA and oligonucleotide monomer synthesis. CAS 113886-71-8. Catalog target purity: Specification on request.
Product profile
2'-O-Me-rC(Ac) is classified as nucleoside or protected nucleoside intermediate (Formula C12H17N3O6; molecular weight 299.28).
2'-O-Me-rC(Ac) — N4-Acetyl-2’-O-methyl-cytidine is a useful compound in the synthesis of functionalized oligonucleotides.
For 2'-O-Me-rC(Ac), reported solubility: Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated). Storage: -20°C Freezer, Under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- Ac-2'-OMe-C
- N4-Ac-2'-OMe-C
- N4-Ac-2'-O-Me-Cr
- N4-Acetyl-2’-OMe-Cytidine
- N-Acetyl-2'-O-methylcytidine
- N4-Acetyl-2'-O-Methyl-cytidine
- Cytidine,N-acetyl-2'-O-methyl-
Useful catalog search terms
- CAS 113886-71-8
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Density | 1.58±0.1 g/cm3(Predicted) |
| pKa | 10.20±0.20(Predicted) |
| Form | Solid |
| Color | White to Off-White |
| InChI | InChI=1S/C12H17N3O6/c1-6(17)13-8-3-4-15(12(19)14-8)11-10(20-2)9(18)7(5-16)21-11/h3-4,7,9-11,16,18H,5H2,1-2H3,(H,13,14,17,19)/t7-,9-,10-,11-/m1/s |
| InChIKey | CYDFBLGNJUNSCC-QCNRFFRDSA-N |
| SMILES | CC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Me-rC(Ac) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rC(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2',3'-dideoxy-C(Ac)
Base-protected Nucleosides · CAS: 119818-52-9
BX-PN-00032',3'-dideoxy-C(Bz)
Base-protected Nucleosides · CAS: 120885-60-1
BX-PN-00052'-F-dG(DMF)
Base-protected Nucleosides · CAS: N/A
BX-PN-00062'-O-4'-C-Locked-5-Me-rC(Bz)
Base-protected Nucleosides · CAS: 206055-81-4
BX-PN-00072'-O-4'-C-Locked-rC(Bz)
Base-protected Nucleosides · CAS: 221229-74-9
BX-PN-00092'-O-4'-C-Locked-rG(iBu)
Base-protected Nucleosides · CAS: 206055-68-7
Frequently asked questions
Can the package size for 2'-O-Me-rC(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0100 and CAS 113886-71-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.